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Ansa Biotechnologies Announces Successful de novo Synthesis of World’s Longest Oligonucleotide at 1005 Bases

  • Published
  • The next frontier in oligonucleotide synthesis is the direct synthesis of gene-length sequences.
  • Ansa synthesized a 1005 base long oligonucleotide with industry-leading accuracy.
  • Ansa will be initiating an Early Access Program for clonal synthetic genes in April 2023 to help researchers obtain sequences that have been difficult to synthesize

“The 1005 base sequence encodes a key part of an AAV vector used for gene therapy development and contains complex features, including strong secondary structures and high GC content, which are extremely challenging to synthesize using conventional methods that require assembly of shorter oligonucleotides.”

View the press release.